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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Human models of noninvasive breast tumors are limited, and the existing in vivo models do not mimic inter- and intratumoral heterogeneity. Ductal carcinoma in situ (DCIS) is the most common type (80%) of noninvasive breast lesions. The aim of this study was to develop an in vivo model whereby the natural progression of human DCIS might be reproduced and studied. To accomplish this goal, the intraductal human-in-mouse (HIM) transplantation model was developed. The resulting models, which mimicked some of the diversity of human noninvasive breast cancers in vivo, were used to show whether subtypes of human DCIS might contain distinct subpopulations of tumor-initiating cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-542X
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pubmed:author |
pubmed-author:AllredD CraigDC,
pubmed-author:BehbodFaribaF,
pubmed-author:EdwardsDavidD,
pubmed-author:HeestandJessica CJC,
pubmed-author:KerbawySofiaS,
pubmed-author:KittrellFrances SFS,
pubmed-author:KobAA,
pubmed-author:LaMarcaHeatherH,
pubmed-author:MedinaDanielD,
pubmed-author:MukhopadhyayPurnaP,
pubmed-author:PolyakKorneliaK,
pubmed-author:RosenJeffrey MJM,
pubmed-author:YehHung-WenHW,
pubmed-author:YoungEvelinE
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R66
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19735549-Animals,
pubmed-meshheading:19735549-Breast Neoplasms,
pubmed-meshheading:19735549-Carcinoma, Ductal,
pubmed-meshheading:19735549-Carcinoma in Situ,
pubmed-meshheading:19735549-Cell Growth Processes,
pubmed-meshheading:19735549-Cell Line, Tumor,
pubmed-meshheading:19735549-Disease Models, Animal,
pubmed-meshheading:19735549-Female,
pubmed-meshheading:19735549-Flow Cytometry,
pubmed-meshheading:19735549-Humans,
pubmed-meshheading:19735549-Mice,
pubmed-meshheading:19735549-Mice, SCID,
pubmed-meshheading:19735549-Neoplasm Transplantation,
pubmed-meshheading:19735549-Transplantation, Heterologous
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pubmed:year |
2009
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pubmed:articleTitle |
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. fbehbod@kumc.edu
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pubmed:publicationType |
Journal Article
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