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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
Hepatocellular carcinoma (HCC) is one of the world's top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9%) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P<0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1872-7980
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
170-7
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pubmed:meshHeading |
pubmed-meshheading:19733004-Adult,
pubmed-meshheading:19733004-Aged,
pubmed-meshheading:19733004-Carcinoma, Hepatocellular,
pubmed-meshheading:19733004-DNA Methylation,
pubmed-meshheading:19733004-Female,
pubmed-meshheading:19733004-Gene Expression Profiling,
pubmed-meshheading:19733004-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19733004-Gene Silencing,
pubmed-meshheading:19733004-Genes, Tumor Suppressor,
pubmed-meshheading:19733004-Humans,
pubmed-meshheading:19733004-Leukemia Inhibitory Factor Receptor alpha Subunit,
pubmed-meshheading:19733004-Liver Neoplasms,
pubmed-meshheading:19733004-Male,
pubmed-meshheading:19733004-Middle Aged,
pubmed-meshheading:19733004-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19733004-Polymorphism, Single Nucleotide,
pubmed-meshheading:19733004-Promoter Regions, Genetic,
pubmed-meshheading:19733004-RNA, Messenger,
pubmed-meshheading:19733004-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19733004-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array.
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pubmed:affiliation |
Department of Surgery II, Graduate School and Medicine, University of Nagoya, Nagoya 466-8550, Japan.
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pubmed:publicationType |
Journal Article
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