|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2009-9-25
|
|
pubmed:abstractText |
Cellular response to external stimuli requires propagation of corresponding signals through molecular signaling pathways. However, signaling pathways are not isolated information highways, but rather interact in a number of ways forming sophisticated signaling networks. Since defects in signaling pathways are associated with many serious diseases, understanding of the crosstalk between them is fundamental for designing molecularly targeted therapy. Unfortunately, we still lack technology that would allow high throughput detailed measurement of activity of individual signaling molecules and their interactions. This necessitates developing methods to prioritize selection of the molecules such that measuring their activity would be most informative for understanding the crosstalk. Furthermore, absence of the reaction coefficients necessary for detailed modeling of signal propagation raises the question whether simple parameter-free models could provide useful information about such pathways.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-10400627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-10647936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-10918300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-11034217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-12702867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-12788545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-12832460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-14534298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-14597658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-14697248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-15579231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16339439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16406679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16564013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16839197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16890793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-16924245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-17057751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-17060902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-17303558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-17447836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-17503395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-18033796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-18508432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-18852469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-38740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-4588055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-7834738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19732446-7834739
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1752-0509
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
88
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19732446-Cell Line,
pubmed-meshheading:19732446-Cell Survival,
pubmed-meshheading:19732446-Computer Simulation,
pubmed-meshheading:19732446-Epidermal Growth Factor,
pubmed-meshheading:19732446-Female,
pubmed-meshheading:19732446-Humans,
pubmed-meshheading:19732446-Insulin,
pubmed-meshheading:19732446-Models, Biological,
pubmed-meshheading:19732446-Ovarian Neoplasms,
pubmed-meshheading:19732446-Signal Transduction,
pubmed-meshheading:19732446-Somatomedins
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
The crosstalk between EGF, IGF, and Insulin cell signaling pathways--computational and experimental analysis.
|
|
pubmed:affiliation |
National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Bethesda, MD, USA. zielinkir@mail.nih.gov
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
|
