Linked Life Data

19732041

Source:http://linkedlifedata.com/resource/pubmed/id/19732041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-6
pubmed:abstractText
Abstract Reactive oxygen species (ROS) and reactive nitrogen species have generally been considered as being highly reactive and cytotoxic molecules. Besides their noxious effects, ROS participate in physiological processes in a carefully regulated manner. By way of example, microbicidal ROS are produced in professional phagocytes, ROS function as short-lived messengers having a role in signal transduction and, among other processes, participate in the synthesis of the iodothyronine hormones, reproduction, apoptosis and necrosis. Because of their ability to mediate a crosstalk between key molecules, their role might be dual (at least in some cases). The levels of ROS increase from a certain age, being associated with various diseases typical of senescence. The aim of this review is to summarize the recent findings on the physiological role of ROS. Other issues addressed are an increase in ROS levels during ageing, and the possibility of the physiological nature of this process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1748-1716
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-35
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Reactive oxygen and nitrogen species in normal physiological processes.
pubmed:affiliation
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Prague, Czech Republic. jana.pourova@faf.cuni.cz
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't