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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-20
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pubmed:abstractText |
Personalized medicine merges genetics, physiology, and patient outcome. Loss of physiologic complexity (heart rate [HR] variability) is a bedside biomarker for autonomic nervous system (ANS) dysfunction. We hypothesized that variability in ANS receptor proteins (genetics) and loss of complexity (physiology) are independently associated with mortality in critical illness.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADRA1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ADRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1528-1140
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
250
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
524-30
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pubmed:meshHeading |
pubmed-meshheading:19730237-Adult,
pubmed-meshheading:19730237-Biological Markers,
pubmed-meshheading:19730237-Female,
pubmed-meshheading:19730237-Genetic Variation,
pubmed-meshheading:19730237-Genotype,
pubmed-meshheading:19730237-Heart Rate,
pubmed-meshheading:19730237-Humans,
pubmed-meshheading:19730237-Individualized Medicine,
pubmed-meshheading:19730237-Injury Severity Score,
pubmed-meshheading:19730237-Intensive Care Units,
pubmed-meshheading:19730237-Logistic Models,
pubmed-meshheading:19730237-Male,
pubmed-meshheading:19730237-Middle Aged,
pubmed-meshheading:19730237-Polymorphism, Genetic,
pubmed-meshheading:19730237-ROC Curve,
pubmed-meshheading:19730237-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:19730237-Receptors, Adrenergic, beta-2,
pubmed-meshheading:19730237-Retrospective Studies,
pubmed-meshheading:19730237-Tennessee,
pubmed-meshheading:19730237-Wounds and Injuries
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pubmed:year |
2009
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pubmed:articleTitle |
Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients.
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pubmed:affiliation |
Division of Trauma and Surgical Critical Care, Vanderbilt University, Nashville, Tennessee, USA. patrick.norris@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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