Linked Life Data

19730158

Source:http://linkedlifedata.com/resource/pubmed/id/19730158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-12-18
pubmed:abstractText
Bioactive factors in human milk (HM) are crucial to the health of newborns, especially preterm infants. These compounds assist in reducing the oxidative stress that may occur as a result of combined exposure to supplemental oxygen and immature physiologic defenses. To identify the components in HM that contribute to its greater resistance to oxidative stress compared with infant formulae, enzymatic hydrolysates of HM were prepared, ultrafiltered, separated, and analyzed for antioxidant potential. The antioxidant activity [microM Trolox equivalent (TE/g)] of nondigested milk, whole digested milk, and derived ultrafiltrates were 80.4 +/- 13.3, 159.0 +/- 5.6, and 127.4 +/- 3.1, respectively. An HPLC fraction denoted as fraction 23 (5274 +/- 630 microM TE/g) was obtained and its constituents identified as tryptophan (Trp), peptides HNPI, and PLAPQA. Scavenging activity was not observed for PLAPQA, whereas moderate activity was associated with HNPI (144 +/- 10.7 microM TE/g) and very high activity to Trp (7986 +/- 468 microM TE/g). Trp addition to HM and two infant formulas significantly increased formulae antioxidant properties. Trp appeared to be a powerful free radical scavenger naturally present in HM. Its antioxidant effects and potential application in the diets of infants, particularly preterm, must be examined further.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1530-0447
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
614-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Tryptophan released from mother's milk has antioxidant properties.
pubmed:affiliation
Chemistry Department, Carleton University, Ottawa, Ontario K1S 5B6, Canada.
pubmed:publicationType
Journal Article