| pubmed-article:19729999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C1335960 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0459471 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C1571705 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0805732 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C1366753 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0812409 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C1150611 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C0205548 | lld:lifeskim |
| pubmed-article:19729999 | lifeskim:mentions | umls-concept:C1548425 | lld:lifeskim |
| pubmed-article:19729999 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:19729999 | pubmed:dateCreated | 2009-9-9 | lld:pubmed |
| pubmed-article:19729999 | pubmed:abstractText | We are using Drosophila follicle cells to study the mechanisms that promote cell motility. Using genetics we identified a gene regulatory network that controls the dynamic pattern of activation of JAK/STAT in anterior follicle cells. Under the influence of a graded signal, Unpaired (UPD), JAK/STAT becomes activated first in a graded fashion. STAT, in turn, locally activates its own repressor, Apontic (APT), a new feedback regulator of JAK/STAT signaling. High levels of JAK/STAT also activate Slow Border Cells (SLBO), which undermines APT-mediated repression. In this way, cells that achieve a high JAK/STAT level maintain SLBO expression and form border cells, which then migrate out of the cell layer. Cells with lower JAK/STAT activity express more APT than SLBO, ultimately lose STAT activity, and remain in the follicular epithelium. To better understand how the graded signal is converted to an all-or-none decision to move or stay, we developed a mathematical model. Simulations using the model reproduce the observed dynamics of JAK/STAT expression in the wild type and in several mutant situations. By combining biological experiments and mathematical modeling, we can achieve a more sophisticated understanding of how cells interpret molecular gradients. | lld:pubmed |
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| pubmed-article:19729999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19729999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19729999 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19729999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19729999 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19729999 | pubmed:issn | 1551-4005 | lld:pubmed |
| pubmed-article:19729999 | pubmed:author | pubmed-author:MeinhardtHans... | lld:pubmed |
| pubmed-article:19729999 | pubmed:author | pubmed-author:MelaniMariana... | lld:pubmed |
| pubmed-article:19729999 | pubmed:author | pubmed-author:MontellDenise... | lld:pubmed |
| pubmed-article:19729999 | pubmed:author | pubmed-author:Starz-GaianoM... | lld:pubmed |
| pubmed-article:19729999 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19729999 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19729999 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:19729999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19729999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19729999 | pubmed:pagination | 2917-25 | lld:pubmed |
| pubmed-article:19729999 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
