Linked Life Data

19729689

Source:http://linkedlifedata.com/resource/pubmed/id/19729689

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-9-4
pubmed:abstractText
To study the influence of ApoAI and ApoB gene polymorphisms on lipid profile in healthy Tamilian volunteers of south India. Genotyping of ApoAI and ApoB polymorphisms was done in 185 subjects by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.The frequency of the M1-, M2- and R- alleles were 21%, 4.3% and 5.4% respectively and were similar to that reported from Asian Indians. An increase of 9.1mg/dl in HDL-C levels was observed with M1-/- genotype when compared to M1+/+. A paradoxical increase in levels of total cholesterol and LDL-C was observed with M2+7divide;- genotype when compared to M2+/+ genotype. Analysis of combination of genotypes of ApoAI revealed no influence on the lipid parameters. ApoB EcoRI had no significant effect on lipid profile. For the first time genotype distribution of ApoAI and ApoB polymorphisms and their effect on lipid profile was established in Tamilians. Only -75G/A polymorphism of ApoAI was significantly associated with HDL7ndash;C levels.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0019-4832
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-4
pubmed:dateRevised
2010-8-13
pubmed:meshHeading
pubmed:articleTitle
Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population.
pubmed:affiliation
Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India. padmaja_25@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't