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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 6
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
Prostate-specific antigen (PSA) is a serine protease that in serum, is predominantly found complexed to the serine protease inhibitor alpha1-antichymotrypsin (ACT). ACT co-localizes with amyloid plaques in Alzheimer's disease (AD) brain and both PSA and ACT are detectable in cerebrospinal fluid (CSF). Therefore, we aimed to determine whether PSA is produced in the brain and whether PSA and PSA-ACT complex levels in CSF can be used as a biomarker for AD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1758-1001
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
477-83
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pubmed:meshHeading |
pubmed-meshheading:19729499-Alzheimer Disease,
pubmed-meshheading:19729499-Biological Markers,
pubmed-meshheading:19729499-Brain,
pubmed-meshheading:19729499-Cognition Disorders,
pubmed-meshheading:19729499-Dementia,
pubmed-meshheading:19729499-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19729499-Female,
pubmed-meshheading:19729499-Frontal Lobe,
pubmed-meshheading:19729499-Humans,
pubmed-meshheading:19729499-Immunoassay,
pubmed-meshheading:19729499-Male,
pubmed-meshheading:19729499-Prostate-Specific Antigen,
pubmed-meshheading:19729499-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19729499-Spectrometry, Fluorescence,
pubmed-meshheading:19729499-Temporal Lobe,
pubmed-meshheading:19729499-alpha 1-Antichymotrypsin
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pubmed:year |
2009
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pubmed:articleTitle |
CSF levels of PSA and PSA-ACT complexes in Alzheimer's disease.
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pubmed:affiliation |
Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands. sd.mulder@vumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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