Source:http://linkedlifedata.com/resource/pubmed/id/19729412
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
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| pubmed:dateCreated |
2009-11-5
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| pubmed:abstractText |
Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (approximately 390,000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
1460-2083
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| pubmed:author |
pubmed-author:AlmgrenPeterP,
pubmed-author:AustGabrielaG,
pubmed-author:BöttcherYvonneY,
pubmed-author:BlüherMatthiasM,
pubmed-author:DietrichKerstinK,
pubmed-author:EnigkBeateB,
pubmed-author:Fischer-RosinskyAntjeA,
pubmed-author:GroopLeifL,
pubmed-author:HoffmannKatrinK,
pubmed-author:KoriathMoritzM,
pubmed-author:KovacsPeterP,
pubmed-author:KrohnKnutK,
pubmed-author:PfeifferAndreasA,
pubmed-author:RaynerNigel WNW,
pubmed-author:RichterOlafO,
pubmed-author:RohmSilvioS,
pubmed-author:SchleinitzDoritD,
pubmed-author:SprangerJoachimJ,
pubmed-author:StumvollMichaelM,
pubmed-author:TönjesAnkeA
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4662-8
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| pubmed:dateRevised |
2011-3-3
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| pubmed:meshHeading |
pubmed-meshheading:19729412-Adult,
pubmed-meshheading:19729412-Aged,
pubmed-meshheading:19729412-Body Height,
pubmed-meshheading:19729412-Cohort Studies,
pubmed-meshheading:19729412-European Continental Ancestry Group,
pubmed-meshheading:19729412-Female,
pubmed-meshheading:19729412-Genetic Variation,
pubmed-meshheading:19729412-Genome-Wide Association Study,
pubmed-meshheading:19729412-Germany,
pubmed-meshheading:19729412-Humans,
pubmed-meshheading:19729412-Male,
pubmed-meshheading:19729412-Middle Aged,
pubmed-meshheading:19729412-Polymorphism, Single Nucleotide,
pubmed-meshheading:19729412-Receptors, G-Protein-Coupled
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| pubmed:year |
2009
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| pubmed:articleTitle |
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
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| pubmed:affiliation |
Department of Medicine, University of Leipzig, Leipzig,Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
|