Linked Life Data

19729339

Source:http://linkedlifedata.com/resource/pubmed/id/19729339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-9-21
pubmed:abstractText
The photochemical behavior is investigated for mequitazine (MQ) illustrating possible mechanisms and photodegradation products formed. Accelerated photolysis is done for MQ under justified stress conditions by subjecting aqueous drug solutions to radiation for specified period of time. Synthesis of the main photodegradants, the sulfoxide, is achieved. Selective quantification of MQ, singly in bulk form, pharmaceutical formulations and/or in the presence of its photodegradants is demonstrated. The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions using a simple colorimetric method based on oxidation of the intact phenothiazine drug by potassium iodate in acid medium to form a red colored product adequate for quantitative estimation of the studied drug.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-3557
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
740-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Photodegradation and photostability-indication of mequitazine.
pubmed:affiliation
Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini St, ET-11562, Cairo, Egypt. eamoety@hotmail.com
pubmed:publicationType
Journal Article