Linked Life Data

19728983

Source:http://linkedlifedata.com/resource/pubmed/id/19728983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2009-9-23
pubmed:abstractText
The anterior pituitary gland, or adenohypophysis (AH), represents the key component of the vertebrate hypothalamo-hypophyseal axis, where it functions at the interphase of the nervous and endocrine system to regulate basic body functions like growth, metabolism and reproduction. For developmental biologists, the adenohypophysis serves as an excellent model system for the studies of organogenesis and differential cell fate specification. Previous research, mainly done in mouse, identified numerous extrinsic signaling cues and intrinsic transcription factors that orchestrate the gland's developmental progression. In the past years, the zebrafish has emerged as a powerful tool to elucidate the genetic networks controlling vertebrate development, behavior and disease. Based on mutants isolated in forward genetic screens and on gene knock-downs using morpholino oligonucleotide (oligo) antisense technology, our current understanding of the molecular machinery driving adenohypophyseal ontogeny could be considerably improved. In addition, comparative analyses have shed further light onto the evolution of this rather recently invented organ. The goal of this review is to summarize current knowledge of the genetic and molecular control of zebrafish pituitary development, with special focus on most recent findings, including some thus far unpublished data from our own laboratory on the transcription factor Six1. In addition, zebrafish data will be discussed in comparison with current understanding of adenohypophysis development in mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-8057
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
312
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
How to make a teleost adenohypophysis: molecular pathways of pituitary development in zebrafish.
pubmed:affiliation
Institute for Developmental Biology, University of Cologne, Gyrhofstr. 17, D-50931 Cologne, Germany. pogodah@uni-koeln.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't