Linked Life Data

19728763

Source:http://linkedlifedata.com/resource/pubmed/id/19728763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-9-4
pubmed:abstractText
The Notch/Jagged signaling pathway is important for cellular differentiation and proliferation. Notch1/Jagged1 can either suppress or promote tumors depending on the cell type and context. beta-catenin, one of the mediators of the Wnt signalling pathway, represents a key element in one of the most important pathways of carcinogenesis. The aim of this study was to examine the expression of Notch1/Jagged1 and beta-catenin in hepatocellular carcinoma and to assign clinicopathological correlations. Immunohistochemical detection of Notch1/Jagged1 and beta-catenin was performed in tissue microarrays including 339 Hepatocellular carcinomas, 174 adjacent non-tumor livers and 94 normal livers. The results showed that the rate of expression was 66%, 98% and 97% for Notch1 and 36%, 85% and 92% for Jagged1 respectively in hepatocellular carcinoma, adjacent non-tumor liver and normal liver. Decreased expression of Notch1/Jagged1 was correlated significantly with Edmondson-Steiner grade. However, nuclear beta-catenin was expressed in 37% of hepatocellular carcinoma tissue, which was significantly higher than its non-tumor counterparts. Increased nuclear beta-catenin expression was correlated with HBs-Ag status and Edmondson-Steiner grade. Moreover, The positive expression of Notch1 was parallel with Jagged1 expression (r =0.235, p=0.000) and reduced Notch1 expression was associated with increased beta-catenin expression in hepatocellular carcinoma (r =-0.125, p =0.023). In conclusion, Notch1/Jagged1 were frequently low expressed in hepatocellular carcinoma and correlated with the high expression of beta-catenin suggesting that downregulation of Notch1/Jagged1 signaling may sustain tumor progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-41
pubmed:meshHeading
pubmed-meshheading:19728763-Adolescent, pubmed-meshheading:19728763-Adult, pubmed-meshheading:19728763-Aged, pubmed-meshheading:19728763-Calcium-Binding Proteins, pubmed-meshheading:19728763-Carcinoma, Hepatocellular, pubmed-meshheading:19728763-Case-Control Studies, pubmed-meshheading:19728763-Child, pubmed-meshheading:19728763-Child, Preschool, pubmed-meshheading:19728763-Female, pubmed-meshheading:19728763-Humans, pubmed-meshheading:19728763-Immunoenzyme Techniques, pubmed-meshheading:19728763-Infant, pubmed-meshheading:19728763-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:19728763-Liver, pubmed-meshheading:19728763-Liver Neoplasms, pubmed-meshheading:19728763-Male, pubmed-meshheading:19728763-Membrane Proteins, pubmed-meshheading:19728763-Middle Aged, pubmed-meshheading:19728763-Prognosis, pubmed-meshheading:19728763-Receptor, Notch1, pubmed-meshheading:19728763-Young Adult, pubmed-meshheading:19728763-beta Catenin
pubmed:year
2009
pubmed:articleTitle
Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma.
pubmed:affiliation
Department of Pathology, The first Affiliated Hospital, SUN YAT-SEN UNIVERSITY, Guang Zhou City, Guang Dong Province, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't