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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6277
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pubmed:dateCreated |
1990-7-31
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pubmed:abstractText |
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
345
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
686-92
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1972777-Amino Acid Sequence,
pubmed-meshheading:1972777-Base Sequence,
pubmed-meshheading:1972777-Cell Differentiation,
pubmed-meshheading:1972777-DNA-Binding Proteins,
pubmed-meshheading:1972777-Down-Regulation,
pubmed-meshheading:1972777-Embryo, Mammalian,
pubmed-meshheading:1972777-Embryo, Nonmammalian,
pubmed-meshheading:1972777-Endoderm,
pubmed-meshheading:1972777-Gene Expression,
pubmed-meshheading:1972777-Genes, Homeobox,
pubmed-meshheading:1972777-Germ Cells,
pubmed-meshheading:1972777-Mesoderm,
pubmed-meshheading:1972777-Molecular Sequence Data,
pubmed-meshheading:1972777-Nucleic Acid Hybridization,
pubmed-meshheading:1972777-Octamer Transcription Factor-3,
pubmed-meshheading:1972777-Oocytes,
pubmed-meshheading:1972777-RNA, Messenger,
pubmed-meshheading:1972777-Stem Cells,
pubmed-meshheading:1972777-Transcription Factors
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pubmed:year |
1990
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pubmed:articleTitle |
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
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pubmed:affiliation |
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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