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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-3
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pubmed:abstractText |
Type 2 diabetes develops due to a combination of insulin resistance and beta-cell failure and current therapeutics aim at both of these underlying causes. Several negative regulators of insulin signaling are known and are the subject of drug discovery efforts. We sought to identify novel contributors to insulin resistance and hence potentially novel targets for therapeutic intervention.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-10066179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-10574462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-10960473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-11171109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-11463863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-11684658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-11752399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12493740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12556524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12730241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12771949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12777378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-12791994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-14657487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-14769918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15143191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15186772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15685170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15713620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15743841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-15860415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-17113751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-17116687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-18669619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-7479768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-8262969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19727444-9670003
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6871
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19727444-Animals,
pubmed-meshheading:19727444-CHO Cells,
pubmed-meshheading:19727444-Cricetinae,
pubmed-meshheading:19727444-Cricetulus,
pubmed-meshheading:19727444-Diabetes Mellitus, Type 2,
pubmed-meshheading:19727444-Forkhead Transcription Factors,
pubmed-meshheading:19727444-Gene Expression Regulation,
pubmed-meshheading:19727444-Gene Library,
pubmed-meshheading:19727444-Genes, Reporter,
pubmed-meshheading:19727444-Humans,
pubmed-meshheading:19727444-Insulin,
pubmed-meshheading:19727444-Insulin Resistance,
pubmed-meshheading:19727444-Insulin-Secreting Cells,
pubmed-meshheading:19727444-Phosphorylation,
pubmed-meshheading:19727444-Proteins,
pubmed-meshheading:19727444-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Negative regulators of insulin signaling revealed in a genome-wide functional screen.
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pubmed:affiliation |
Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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