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rdf:type |
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lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0012655,
umls-concept:C0013227,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0030946,
umls-concept:C0033607,
umls-concept:C0042776,
umls-concept:C0080194,
umls-concept:C0205419,
umls-concept:C0328767,
umls-concept:C0332307
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pubmed:issue |
3
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pubmed:dateCreated |
2009-10-29
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pubmed:abstractText |
Protease (PR) inhibitors (PIs) were designed against subtype B virus of human immunodeficiency virus type 1 (HIV-1), but believed to retain its activity against most of the other subtypes. CRF01_AE PR (AE-PR) contains background mutations that are presumed to alter the drug susceptibility of PR. In addition, amino acid variations found in HIV-1 Gag potentially affect the drug susceptibility or catalytic efficiency of PR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1944-7884
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pubmed:author |
pubmed-author:AuwanitWattanaW,
pubmed-author:IkutaKazuyoshiK,
pubmed-author:Isarangkura-na-ayuthayaPanasdaP,
pubmed-author:JinnopatPiyamatP,
pubmed-author:KameokaMasanoriM,
pubmed-author:KameokaYokoY,
pubmed-author:KitagawaYukikoY,
pubmed-author:SawanpanyalertPathomP,
pubmed-author:SiripanyaphinyoUampornU,
pubmed-author:TokunagaKenzoK,
pubmed-author:UtacheePirapornP,
pubmed-author:de SilvaU ChandimalUC
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
320-8
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pubmed:meshHeading |
pubmed-meshheading:19727001-Amino Acid Sequence,
pubmed-meshheading:19727001-Drug Resistance, Viral,
pubmed-meshheading:19727001-Gene Expression Regulation, Viral,
pubmed-meshheading:19727001-HIV Infections,
pubmed-meshheading:19727001-HIV Protease,
pubmed-meshheading:19727001-HIV Protease Inhibitors,
pubmed-meshheading:19727001-HIV-1,
pubmed-meshheading:19727001-Humans,
pubmed-meshheading:19727001-Molecular Sequence Data,
pubmed-meshheading:19727001-Mutation,
pubmed-meshheading:19727001-Thailand,
pubmed-meshheading:19727001-gag Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2009
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pubmed:articleTitle |
Impact of amino acid variations in Gag and protease of HIV type 1 CRF01_AE strains on drug susceptibility of virus to protease inhibitors.
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pubmed:affiliation |
Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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