| pubmed-article:19726767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19726767 | lifeskim:mentions | umls-concept:C0034789 | lld:lifeskim |
| pubmed-article:19726767 | lifeskim:mentions | umls-concept:C1706296 | lld:lifeskim |
| pubmed-article:19726767 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:19726767 | lifeskim:mentions | umls-concept:C1326228 | lld:lifeskim |
| pubmed-article:19726767 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19726767 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19726767 | pubmed:dateCreated | 2009-9-3 | lld:pubmed |
| pubmed-article:19726767 | pubmed:abstractText | B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-kappaB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes. | lld:pubmed |
| pubmed-article:19726767 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19726767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19726767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19726767 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19726767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19726767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19726767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19726767 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19726767 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19726767 | pubmed:author | pubmed-author:KhanWasif NWN | lld:pubmed |
| pubmed-article:19726767 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19726767 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19726767 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:19726767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19726767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19726767 | pubmed:pagination | 3561-7 | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:meshHeading | pubmed-meshheading:19726767... | lld:pubmed |
| pubmed-article:19726767 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19726767 | pubmed:articleTitle | B cell receptor and BAFF receptor signaling regulation of B cell homeostasis. | lld:pubmed |
| pubmed-article:19726767 | pubmed:affiliation | Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. wnkhan@med.miami.edu | lld:pubmed |
| pubmed-article:19726767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19726767 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:19726767 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:115650 | entrezgene:pubmed | pubmed-article:19726767 | lld:entrezgene |
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