| pubmed-article:19726655 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:19726655 | lifeskim:mentions | umls-concept:C2348042 | lld:lifeskim |
| pubmed-article:19726655 | pubmed:issue | 35 | lld:pubmed |
| pubmed-article:19726655 | pubmed:dateCreated | 2009-9-3 | lld:pubmed |
| pubmed-article:19726655 | pubmed:abstractText | At a number of synapses, long-term potentiation (LTP) can be expressed by an increase in presynaptic strength, but it is unknown whether presynaptic LTP is expressed solely through an increase in the probability that a single vesicle is released or whether it can increase multivesicular release (MVR). Here, we show that presynaptic LTP decreases inhibition of AMPA receptor EPSCs by a low-affinity antagonist at parallel fiber-molecular layer interneuron (PF-MLI) synapses. This indicates that LTP induction results in larger glutamate concentration transients in the synaptic cleft, a result indicative of MVR, and suggests that MVR can be modified by long-term plasticity. A similar decrease in inhibition was observed when release probability (PR) was increased by forskolin, elevated extracellular Ca2+, and paired-pulse facilitation. Furthermore, we show that MVR may occur under baseline physiological conditions, as inhibition increased when P(R) was lowered by reducing extracellular Ca2+ or by activating presynaptic adenosine receptors. These results suggest that at PF-MLI synapses, MVR occurs under control conditions and is increased when PR is elevated by both short- and long-term plasticity mechanisms. | lld:pubmed |
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| pubmed-article:19726655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19726655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19726655 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19726655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19726655 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19726655 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:19726655 | pubmed:author | pubmed-author:JahrCraig ECE | lld:pubmed |
| pubmed-article:19726655 | pubmed:author | pubmed-author:PughJason RJR | lld:pubmed |
| pubmed-article:19726655 | pubmed:author | pubmed-author:BenderVanessa... | lld:pubmed |
| pubmed-article:19726655 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19726655 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:19726655 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:19726655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19726655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19726655 | pubmed:pagination | 10974-8 | lld:pubmed |
| pubmed-article:19726655 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:meshHeading | pubmed-meshheading:19726655... | lld:pubmed |
| pubmed-article:19726655 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19726655 | pubmed:articleTitle | Presynaptically expressed long-term potentiation increases multivesicular release at parallel fiber synapses. | lld:pubmed |
| pubmed-article:19726655 | pubmed:affiliation | Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA. | lld:pubmed |
| pubmed-article:19726655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19726655 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19726655 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19726655 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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