Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
35
pubmed:dateCreated
2009-9-3
pubmed:abstractText
At a number of synapses, long-term potentiation (LTP) can be expressed by an increase in presynaptic strength, but it is unknown whether presynaptic LTP is expressed solely through an increase in the probability that a single vesicle is released or whether it can increase multivesicular release (MVR). Here, we show that presynaptic LTP decreases inhibition of AMPA receptor EPSCs by a low-affinity antagonist at parallel fiber-molecular layer interneuron (PF-MLI) synapses. This indicates that LTP induction results in larger glutamate concentration transients in the synaptic cleft, a result indicative of MVR, and suggests that MVR can be modified by long-term plasticity. A similar decrease in inhibition was observed when release probability (PR) was increased by forskolin, elevated extracellular Ca2+, and paired-pulse facilitation. Furthermore, we show that MVR may occur under baseline physiological conditions, as inhibition increased when P(R) was lowered by reducing extracellular Ca2+ or by activating presynaptic adenosine receptors. These results suggest that at PF-MLI synapses, MVR occurs under control conditions and is increased when PR is elevated by both short- and long-term plasticity mechanisms.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-10516326, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-10662825, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-10844011, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-11683999, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-11797010, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-11826273, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-12055631, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-12134155, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-12165473, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-12879969, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-1359647, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-14532002, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-14617674, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-14999062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-15071110, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-16354924, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-16399689, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-1654950, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-1684726, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-17135411, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-17392457, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-18064422, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-18663469, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-19198604, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-2114039, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-2164158, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-2167454, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-7507341, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-7675078, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-7916482, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-8607997, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-9252190, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-9348337, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-9763467, http://linkedlifedata.com/resource/pubmed/commentcorrection/19726655-9856469
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10974-8
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Presynaptically expressed long-term potentiation increases multivesicular release at parallel fiber synapses.
pubmed:affiliation
Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural