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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-8
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pubmed:abstractText |
Both attention biases to threat and a serotonin-transporter gene polymorphism (5-HTTLPR) have been linked to heightened neural activation to threat and the emergence of anxiety. The short allele of 5-HTTLPR may act via its effect on neurotransmitter availability, while attention biases shape broad patterns of cognitive processing. We examined individual differences in attention bias to emotion faces as a function of 5-HTTLPR genotype. Adolescents (N=117) were classified for presumed SLC6A4 expression based on 5-HTTLPR-low (SS, SL(G), or L(G)L(G)), intermediate (SL(A) or L(A)L(G)), or high (L(A)L(A)). Participants completed the dot-probe task, measuring attention biases toward or away from angry and happy faces. Biases for angry faces increased with the genotype-predicted neurotransmission levels (low>intermediate>high). The reverse pattern was evident for happy faces. The data indicate a linear relation between 5-HTTLPR allelic status and attention biases to emotion, demonstrating a genetic mechanism for biased attention using ecologically valid stimuli that target socioemotional adaptation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-12130784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-16642437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17201568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17324031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17347341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17453062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17679635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-17949693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-18313034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-18414408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-18458208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-18729589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-18754004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-19437301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-19564050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-8929413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-9204677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19723555-9435761
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-6246
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-71
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pubmed:dateRevised |
2011-9-29
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pubmed:meshHeading |
pubmed-meshheading:19723555-Adolescent,
pubmed-meshheading:19723555-Analysis of Variance,
pubmed-meshheading:19723555-Attention,
pubmed-meshheading:19723555-Bias (Epidemiology),
pubmed-meshheading:19723555-Emotions,
pubmed-meshheading:19723555-Facial Expression,
pubmed-meshheading:19723555-Female,
pubmed-meshheading:19723555-Genotype,
pubmed-meshheading:19723555-Humans,
pubmed-meshheading:19723555-Longitudinal Studies,
pubmed-meshheading:19723555-Male,
pubmed-meshheading:19723555-Neuropsychological Tests,
pubmed-meshheading:19723555-Photic Stimulation,
pubmed-meshheading:19723555-Polymorphism, Single Nucleotide,
pubmed-meshheading:19723555-Psychiatric Status Rating Scales,
pubmed-meshheading:19723555-Reaction Time,
pubmed-meshheading:19723555-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces.
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pubmed:affiliation |
Department of Psychology, George Mason University, Fairfax, VA 22030, United States. kperezed@gmu.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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