Linked Life Data

19723543

Source:http://linkedlifedata.com/resource/pubmed/id/19723543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-9-28
pubmed:abstractText
Here we show that absence of Sep-tRNA:Sec-tRNA synthase (SepSecS) a key enzyme required for the synthesis of the three trypanosomal selenoproteins does not affect growth of bloodstream forms of Trypanosoma brucei. Both life cycle stages of T. brucei are highly sensitive to auranofin, a compound known to target selenoproteins. However, the same sensitivity is observed in the SepSecS double knockout cell lines indicating that the trypanocidal action of auranofin is not connected to selenoproteins. Finally, we show that absence of selenoproteins does not increase sensitivity to H(2)O(2)-induced oxidative stress. Thus in cell culture normal growth of procyclic and bloodstream T. brucei does not depend on selenoproteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-9428
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The selenoproteome is dispensable in bloodstream forms of Trypanosoma brucei.
pubmed:affiliation
Department of Chemistry and Biochemistry, University of Bern, Freiestr. 3, CH-3012 Bern, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't