| pubmed-article:19723089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19723089 | lifeskim:mentions | umls-concept:C0085508 | lld:lifeskim |
| pubmed-article:19723089 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:19723089 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19723089 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:19723089 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:19723089 | pubmed:dateCreated | 2009-9-2 | lld:pubmed |
| pubmed-article:19723089 | pubmed:abstractText | Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-kappaB (NF-kappaB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ(2) inhibits apoptosis by regulating apoptotic gene expression and NF-kappaB activation in gastric epithelial cells infected with CagA+, VacA+H. pylori in a Korean isolate (HP99). 15d-PGJ(2) was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ(2) induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-kappaB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ(2) inhibits apoptotic cell death by inhibiting NF-kappaB activation and apoptotic gene expression in gastric epithelial cells. | lld:pubmed |
| pubmed-article:19723089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19723089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19723089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19723089 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19723089 | pubmed:issn | 1749-6632 | lld:pubmed |
| pubmed-article:19723089 | pubmed:author | pubmed-author:KimHyeyoungH | lld:pubmed |
| pubmed-article:19723089 | pubmed:author | pubmed-author:KimKyung... | lld:pubmed |
| pubmed-article:19723089 | pubmed:author | pubmed-author:ChaBoramB | lld:pubmed |
| pubmed-article:19723089 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19723089 | pubmed:volume | 1171 | lld:pubmed |
| pubmed-article:19723089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19723089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19723089 | pubmed:pagination | 457-63 | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:meshHeading | pubmed-meshheading:19723089... | lld:pubmed |
| pubmed-article:19723089 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19723089 | pubmed:articleTitle | 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. | lld:pubmed |
| pubmed-article:19723089 | pubmed:affiliation | Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project, Yonsei University College of Human Ecology, Seoul, Korea. | lld:pubmed |
| pubmed-article:19723089 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19723089 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4790 | entrezgene:pubmed | pubmed-article:19723089 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19723089 | lld:entrezgene |
