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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-9-2
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pubmed:abstractText |
Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-kappaB (NF-kappaB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ(2) inhibits apoptosis by regulating apoptotic gene expression and NF-kappaB activation in gastric epithelial cells infected with CagA+, VacA+H. pylori in a Korean isolate (HP99). 15d-PGJ(2) was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ(2) induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-kappaB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ(2) inhibits apoptotic cell death by inhibiting NF-kappaB activation and apoptotic gene expression in gastric epithelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxy-delta(12,14)-prostaglandin...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/VacA protein, Helicobacter pylori,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/cagA protein, Helicobacter pylori
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1749-6632
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
1171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-63
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pubmed:meshHeading |
pubmed-meshheading:19723089-Adenocarcinoma,
pubmed-meshheading:19723089-Antigens, Bacterial,
pubmed-meshheading:19723089-Apoptosis,
pubmed-meshheading:19723089-Bacterial Proteins,
pubmed-meshheading:19723089-Blotting, Western,
pubmed-meshheading:19723089-Cell Line, Tumor,
pubmed-meshheading:19723089-DNA Fragmentation,
pubmed-meshheading:19723089-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:19723089-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19723089-Helicobacter pylori,
pubmed-meshheading:19723089-Humans,
pubmed-meshheading:19723089-NF-kappa B,
pubmed-meshheading:19723089-Oligonucleotides,
pubmed-meshheading:19723089-Prostaglandin D2,
pubmed-meshheading:19723089-Protein Binding,
pubmed-meshheading:19723089-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19723089-Stomach Neoplasms,
pubmed-meshheading:19723089-bcl-2-Associated X Protein
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pubmed:year |
2009
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pubmed:articleTitle |
15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells.
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pubmed:affiliation |
Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project, Yonsei University College of Human Ecology, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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