Linked Life Data

19723036

Source:http://linkedlifedata.com/resource/pubmed/id/19723036

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-9-2
pubmed:abstractText
One strategy for cancer management consists of promoting selective apoptosis of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a proapoptotic cytokine, is a promising anticancer agent because of its ability to selectively induce apoptosis in established tumor cell lines but not in nontransformed cells. However, many tumors have developed mechanisms of resistance against killing by TRAIL. Whether or not the transcription factor nuclear factor (kappaB) is involved in TRAIL resistance is uncertain, and this short review aims to summarize currently available data on this question.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1171
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-49
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?
pubmed:affiliation
Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland.
pubmed:publicationType
Journal Article, Review