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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-7-9
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pubmed:abstractText |
The authors examined cytomegalovirus (CMV)-infected tissues and Hodgkin's Disease (HD) cases with immunohistochemical assays for Leu-M1 and CMV. The cytologic characteristics were correlated with immunostaining patterns. Cytomegalovirus-infected cells in lymph node, lung, and esophagus sections showed Cowdry type A inclusions, and many had granular cytoplasmic inclusions. All infected cells showed nuclear staining with an anti-CMV antibody. Leu-M1 reacted with CMV-infected cells in cytoplasmic areas, particularly near the nucleus simulating the characteristic staining pattern of Reed-Sternberg (R-S) cells. Cytoplasmic staining intensified as the intranuclear inclusions increased in size. Reed-Sternberg cells showed characteristic Leu-M1 positivity along the cell membrane and golgi zone. At times, Leu-M1 staining of CMV-infected cells was indistinguishable from that of R-S cells. None of the R-S cells reacted with the antibody to CMV. Recognition of the reactivity of Leu-M1 with CMV-infected cells is important in avoiding misdiagnosis of CMV lymphadenitis as HD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-168685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3064216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3092632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3155594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3301627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3511719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-3907362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-6166661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-6179666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-6649082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-6741873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1972001-6859389
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
989-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1972001-Adult,
pubmed-meshheading:1972001-Aged,
pubmed-meshheading:1972001-Antigens, CD,
pubmed-meshheading:1972001-Antigens, CD15,
pubmed-meshheading:1972001-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:1972001-Cytomegalovirus Infections,
pubmed-meshheading:1972001-Diagnostic Errors,
pubmed-meshheading:1972001-Female,
pubmed-meshheading:1972001-Hodgkin Disease,
pubmed-meshheading:1972001-Humans,
pubmed-meshheading:1972001-Immunoenzyme Techniques,
pubmed-meshheading:1972001-Male,
pubmed-meshheading:1972001-Middle Aged,
pubmed-meshheading:1972001-Tumor Markers, Biological
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pubmed:year |
1990
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pubmed:articleTitle |
Cytomegalovirus-infected cells express Leu-M1 antigen. A potential source of diagnostic error.
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pubmed:affiliation |
Laboratory Medicine Department, National Naval Medical Center, Bethesda, Maryland 20814.
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pubmed:publicationType |
Journal Article
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