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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-7-11
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pubmed:abstractText |
We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Docosahexaenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosapentaenoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-6,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Linolenic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Linolenic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-9165
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1028-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1971991-Adult,
pubmed-meshheading:1971991-Blood Pressure,
pubmed-meshheading:1971991-Cholesterol, LDL,
pubmed-meshheading:1971991-Dietary Fats, Unsaturated,
pubmed-meshheading:1971991-Docosahexaenoic Acids,
pubmed-meshheading:1971991-Double-Blind Method,
pubmed-meshheading:1971991-Eicosapentaenoic Acid,
pubmed-meshheading:1971991-Fatty Acids, Omega-3,
pubmed-meshheading:1971991-Fatty Acids, Omega-6,
pubmed-meshheading:1971991-Fatty Acids, Unsaturated,
pubmed-meshheading:1971991-Humans,
pubmed-meshheading:1971991-Linoleic Acid,
pubmed-meshheading:1971991-Linoleic Acids,
pubmed-meshheading:1971991-Linolenic Acids,
pubmed-meshheading:1971991-Male,
pubmed-meshheading:1971991-Middle Aged,
pubmed-meshheading:1971991-Triglycerides,
pubmed-meshheading:1971991-alpha-Linolenic Acid
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pubmed:year |
1990
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pubmed:articleTitle |
n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants.
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pubmed:affiliation |
CSIRO Division of Human Nutrition, Adelaide, South Australia.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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