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pubmed-article:19718441pubmed:abstractTextIn genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed during a pre-defined enrollment period. Such an ascertainment procedure is typically taken into account in the statistical analysis of the familial data by constructing either a retrospective or prospective likelihood expression, which conditions on the ascertainment event. Both of these approaches lead to a substantial loss of valuable data.lld:pubmed
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pubmed-article:19718441pubmed:articleTitleFull likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information.lld:pubmed
pubmed-article:19718441pubmed:affiliationDepartment of Public Health, University of Helsinki, Helsinki, Finland. janne.pitkaniemi@helsinki.filld:pubmed
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