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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-29
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pubmed:abstractText |
Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized beta-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by beta-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-10411913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-10498690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-11207364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-11371349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-11445543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-11782404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-12756226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-12923059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-14668413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15084463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15339667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15538382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15829953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15961525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-15978571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-16103225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-16162033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-16251184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17018284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17159988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17507982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17643369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17690294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-17690295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-18347094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-18371452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-18385740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-18593557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-19786951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-7958926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-9488439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-9697701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19718027-9845363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine...,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf7l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1546-1718
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1068-75
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pubmed:dateRevised |
2011-2-16
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pubmed:meshHeading |
pubmed-meshheading:19718027-Animals,
pubmed-meshheading:19718027-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:19718027-Cell Differentiation,
pubmed-meshheading:19718027-Cells, Cultured,
pubmed-meshheading:19718027-Embryo, Mammalian,
pubmed-meshheading:19718027-Epithelial Cells,
pubmed-meshheading:19718027-Female,
pubmed-meshheading:19718027-Homeostasis,
pubmed-meshheading:19718027-Male,
pubmed-meshheading:19718027-Mice,
pubmed-meshheading:19718027-Mice, Knockout,
pubmed-meshheading:19718027-Mice, Nude,
pubmed-meshheading:19718027-Nerve Tissue Proteins,
pubmed-meshheading:19718027-Signal Transduction,
pubmed-meshheading:19718027-Skin,
pubmed-meshheading:19718027-Stem Cells,
pubmed-meshheading:19718027-TCF Transcription Factors,
pubmed-meshheading:19718027-Transcription Factor 7-Like 1 Protein,
pubmed-meshheading:19718027-Wnt Proteins,
pubmed-meshheading:19718027-Wound Healing,
pubmed-meshheading:19718027-beta Catenin
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pubmed:year |
2009
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pubmed:articleTitle |
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
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pubmed:affiliation |
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA.
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