Linked Life Data

19716362

Source:http://linkedlifedata.com/resource/pubmed/id/19716362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-10-9
pubmed:abstractText
Ferritin, an iron storage protein, plays an essential role in iron homeostasis and a wide range of physiologic processes. Ferritin alleviates oxidative stress by regulating cellular labile iron concentration. The tumor suppressor p53 is induced upon iron depletion, and controls reactive oxygen species level. Although some functional connections between ferritin and p53 were implied in several reports, the direct links between ferritin and p53 has not yet been investigated. Here we report that ferritin physically interacts with p53 upon oxidative stress. Ferritin increases p53 protein level and p53 transcriptional activity in ferroxidase activity independent manner. Ferritin knocked down cells show retarded induction of p53 target genes upon oxidative stress. These findings suggest that ferritin cooperates with p53 to cope with oxidative stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
389
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-404
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Ferritin binds and activates p53 under oxidative stress.
pubmed:affiliation
National Research Laboratory for Metabolic Checkpoint, Department of Biomedical Sciences & Biochemistry, Seoul National University College of Medicine, Seoul, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't