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pubmed-article:19715559pubmed:abstractTextThe Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae that is positioned close to the centrosome in a microtubule-dependent manner. How this organisation is achieved and retained is not well understood. GMAP210 is a long coiled-coil cis-Golgi associated protein that plays a role in maintaining Golgi ribbon integrity and position and contributes to the formation of the primary cilium. An amphipathic alpha-helix able to bind liposomes in vitro has been recently identified at the first 38 amino acids of the protein (amphipathic lipid-packing sensor motif), and an ARF1-binding domain (Grip-related Arf-binding domain) was found at the C-terminus. To which type of membranes these two GMAP210 regions bind in vivo and how this contributes to GMAP210 localisation and function remains to be investigated.lld:pubmed
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pubmed-article:19715559pubmed:articleTitleGolgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms.lld:pubmed
pubmed-article:19715559pubmed:affiliationCABIMER-CSIC, Seville, Spain. jesus.cardenas@cabimer.eslld:pubmed
pubmed-article:19715559pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19715559pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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