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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-6-26
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pubmed:abstractText |
The human promyelocytic THP-1 cell line has been found to support the growth of Leishmania parasites. THP-1 cells, differentiated with retinoic acid, cease replication while remaining in suspension. 72 +/- 8% of THP-1 cells became infected after inoculation with promastigotes of several Old and New World Leishmania species. The resulting amastigotes (19 +/- 5 per infected cell) were easy to harvest, capable of reinfecting cultures of normal human cells and, in the case of L. major and L. infantum, caused specific lesions in BALB/c mice. This culture system should facilitate biochemical and immunological studies on amastigotes and be of use in screening anti-parasite drugs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0001-706X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1971494-Animals,
pubmed-meshheading:1971494-Humans,
pubmed-meshheading:1971494-Leishmania,
pubmed-meshheading:1971494-Leishmania donovani,
pubmed-meshheading:1971494-Leishmania tropica,
pubmed-meshheading:1971494-Leukemia, Myeloid,
pubmed-meshheading:1971494-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:1971494-Mice,
pubmed-meshheading:1971494-Mice, Inbred BALB C,
pubmed-meshheading:1971494-Monocytes,
pubmed-meshheading:1971494-Tretinoin,
pubmed-meshheading:1971494-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Interactions between the human monocytic leukaemia THP-1 cell line and Old and New World species of Leishmania.
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pubmed:affiliation |
INSERM U313, CHU Pitie-Salpêtrière, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|