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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0026844,
umls-concept:C0037083,
umls-concept:C0062534,
umls-concept:C0205160,
umls-concept:C0206454,
umls-concept:C0221908,
umls-concept:C0441472,
umls-concept:C0441712,
umls-concept:C1135918,
umls-concept:C1710082,
umls-concept:C1819635
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pubmed:issue |
7
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pubmed:dateCreated |
2009-10-2
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pubmed:abstractText |
Neointimal hyperplasia contributes to atherosclerosis and restenosis after percutaneous coronary intervention. Vascular injury in each of these conditions results in the release of mitogenic growth factors and hormones that contribute to pathological vascular smooth muscle cell growth and inflammation. Hepatocyte growth factor (HGF) is known as an antiinflammatory growth factor, although it is downregulated in injured tissue. However, the precise mechanism how HGF reduces inflammation is unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/EGFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/INPPL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/MET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/heparin-binding EGF-like growth...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
667-75, 13 p following 675
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19713535-Angiotensin II,
pubmed-meshheading:19713535-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19713535-Animals,
pubmed-meshheading:19713535-Atherosclerosis,
pubmed-meshheading:19713535-Cell Proliferation,
pubmed-meshheading:19713535-Cells, Cultured,
pubmed-meshheading:19713535-Hepatocyte Growth Factor,
pubmed-meshheading:19713535-Humans,
pubmed-meshheading:19713535-Hyperplasia,
pubmed-meshheading:19713535-Inflammation,
pubmed-meshheading:19713535-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19713535-Ligands,
pubmed-meshheading:19713535-Mice,
pubmed-meshheading:19713535-Mice, Inbred C57BL,
pubmed-meshheading:19713535-Mice, Transgenic,
pubmed-meshheading:19713535-Muscle, Smooth, Vascular,
pubmed-meshheading:19713535-Myocytes, Smooth Muscle,
pubmed-meshheading:19713535-Phosphoric Monoester Hydrolases,
pubmed-meshheading:19713535-Proteasome Endopeptidase Complex,
pubmed-meshheading:19713535-Protein Processing, Post-Translational,
pubmed-meshheading:19713535-Protein Transport,
pubmed-meshheading:19713535-Proto-Oncogene Proteins,
pubmed-meshheading:19713535-Proto-Oncogene Proteins c-met,
pubmed-meshheading:19713535-RNA Interference,
pubmed-meshheading:19713535-Reactive Oxygen Species,
pubmed-meshheading:19713535-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19713535-Receptors, Growth Factor,
pubmed-meshheading:19713535-Signal Transduction,
pubmed-meshheading:19713535-Superoxide Dismutase,
pubmed-meshheading:19713535-Time Factors,
pubmed-meshheading:19713535-Transfection,
pubmed-meshheading:19713535-Ubiquitination
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pubmed:year |
2009
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pubmed:articleTitle |
Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells.
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pubmed:affiliation |
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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