Linked Life Data

19712984

Source:http://linkedlifedata.com/resource/pubmed/id/19712984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-11-5
pubmed:abstractText
The cytochromes 2 C19 2* loss of function polymorphism has recently been shown to be associated with decreased platelet reactivity (PR) inhibition after clopidogrel loading dose (LD) and an excess in thrombotic events following percutaneous coronary intervention (PCI). We aimed to investigate if an optimal PR inhibition could be obtained in patients homozygotes for this alleles using adjusted LD of clopidogrel according to platelet reactivity monitoring. Post-treatment PR was measured using the VASP index. Dose adjustment was performed in order to obtain a PR <50% using additional clopidogrel LD. Direct sequencing was used to select homozygotes for CYP 2C19 2* alleles. Six patients with the loss of function polymorphism were recruited. The mean VASP index was 53.7 ± 16.2% after the first LD of clopidogrel. Four patients had a VASP index >50% and were therefore considered to have high on treatment PR. Using up to 3 additional 600 mg LD of clopidogrel we were able to obtain a VASP <50% in all these patients. The present study is the first to suggest that in homozygotes for CYP 2C19 2* loss of function polymorphism, increased loading dose of 55 clopidogrel is efficient to obtain an optimal level PR inhibition in patients undergoing PCI.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1874-1754
pubmed:author
pubmed:copyrightInfo
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2* loss of function polymorphism.
pubmed:publicationType
Letter