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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-10-19
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pubmed:abstractText |
Our original studies reported an association between the iron-metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effect on cell proliferation, iron is involved in both fetal development and cancer. We hypothesize that HFE links higher infant birth weight with leukemia risk and that maternal HFE genotype modifies this association.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/CD71 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HFE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/hepcidin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1545-5017
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1242-8
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pubmed:meshHeading |
pubmed-meshheading:19711434-Adolescent,
pubmed-meshheading:19711434-Adult,
pubmed-meshheading:19711434-Antigens, CD,
pubmed-meshheading:19711434-Antimicrobial Cationic Peptides,
pubmed-meshheading:19711434-Birth Weight,
pubmed-meshheading:19711434-Child,
pubmed-meshheading:19711434-Child, Preschool,
pubmed-meshheading:19711434-England,
pubmed-meshheading:19711434-Female,
pubmed-meshheading:19711434-Fetal Blood,
pubmed-meshheading:19711434-Genetic Predisposition to Disease,
pubmed-meshheading:19711434-Hemochromatosis,
pubmed-meshheading:19711434-Histocompatibility Antigens Class I,
pubmed-meshheading:19711434-Humans,
pubmed-meshheading:19711434-Infant,
pubmed-meshheading:19711434-Infant, Low Birth Weight,
pubmed-meshheading:19711434-Infant, Newborn,
pubmed-meshheading:19711434-Iron,
pubmed-meshheading:19711434-Male,
pubmed-meshheading:19711434-Membrane Proteins,
pubmed-meshheading:19711434-Models, Biological,
pubmed-meshheading:19711434-Polymorphism, Single Nucleotide,
pubmed-meshheading:19711434-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19711434-Pregnancy,
pubmed-meshheading:19711434-Pregnancy Complications,
pubmed-meshheading:19711434-Receptors, Transferrin,
pubmed-meshheading:19711434-Risk,
pubmed-meshheading:19711434-Sex Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk.
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pubmed:affiliation |
Northern Institute for Cancer Research, Newcastle University, Newcastle, UK. dorakmt@dorak.info
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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