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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8699
|
| pubmed:dateCreated |
1990-6-18
|
| pubmed:abstractText |
Human papilloma virus (HPV) DNA sequences (HPV types 16, 18, 33, 35 or uncharacterized) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2.6 times higher risk of overall relapse (p less than 0.05) and 4.5 times higher risk of distant metastases (p less than 0.01). The 24-month relapse-free survival rate in HPV-positive patients was significantly higher than that in HPV-negative patients (77% vs 40%), and the difference was similar (91% vs 56%) among those who were node-negative. These data indicate that HPV-negative cervical carcinomas may represent a biologically distinct subset of tumours that carry a poorer prognosis than do HPV-positive cancers.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
335
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1171-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1971033-Adenocarcinoma,
pubmed-meshheading:1971033-Adult,
pubmed-meshheading:1971033-Analysis of Variance,
pubmed-meshheading:1971033-Carcinoma, Squamous Cell,
pubmed-meshheading:1971033-DNA, Viral,
pubmed-meshheading:1971033-DNA Probes,
pubmed-meshheading:1971033-Evaluation Studies as Topic,
pubmed-meshheading:1971033-Female,
pubmed-meshheading:1971033-Follow-Up Studies,
pubmed-meshheading:1971033-Humans,
pubmed-meshheading:1971033-Lymphatic Metastasis,
pubmed-meshheading:1971033-Middle Aged,
pubmed-meshheading:1971033-Neoplasm Recurrence, Local,
pubmed-meshheading:1971033-Neoplasm Staging,
pubmed-meshheading:1971033-Papillomaviridae,
pubmed-meshheading:1971033-Polymerase Chain Reaction,
pubmed-meshheading:1971033-Prognosis,
pubmed-meshheading:1971033-Risk Factors,
pubmed-meshheading:1971033-Uterine Cervical Neoplasms
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA.
|
| pubmed:affiliation |
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy IGR, Villejuif, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|