Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-16
pubmed:abstractText
Sucrose intake has been shown to suppress increased adrenocorticotropic hormone (ACTH) levels in adrenalectomized rats, suggesting that increased cerebral energy supply can compensate for the loss of glucocorticoid feedback inhibition of the hypothalamo-pituitary-adrenal axis. We hypothesized that glucose infusion might acutely down-regulate increased ACTH secretion in patients with Addison disease. We studied 8 patients with primary adrenal insufficiency (Addison group) with short-term discontinuation of hydrocortisone substitution and 8 matched healthy controls in 2 randomized conditions. Subjects received either intravenous glucose infusion (0.75 g glucose per kilogram body weight for 2.5 hours) or placebo. Concentrations of ACTH, cortisol, catecholamines, growth hormone, glucagon, and insulin were measured; and cognitive functions as well as neuroglycopenic and autonomic symptoms were assessed. The ACTH concentrations were not affected by glucose infusion either in the Addison or in the control group. Likewise, concentrations of cortisol, epinephrine, norepinephrine, growth hormone, and glucagon remained unchanged in both groups. Neurocognitive performance and symptom scores were likewise not affected. Independent of glucose infusion, attention of the Addison patients was impaired in comparison with the control group. Our study in patients with Addison disease was not able to support the assumption of a compensatory effect of intravenous glucose infusion on hormonal parameters and neurocognitive symptoms in states of chronic cortisol deficiency. Further studies should examine whether different regimens of glucose administration are more effective.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1532-8600
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1825-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19709691-Addison Disease, pubmed-meshheading:19709691-Adrenocorticotropic Hormone, pubmed-meshheading:19709691-Adult, pubmed-meshheading:19709691-Aged, pubmed-meshheading:19709691-Attention, pubmed-meshheading:19709691-Cognition, pubmed-meshheading:19709691-Female, pubmed-meshheading:19709691-Glucose, pubmed-meshheading:19709691-Hormones, pubmed-meshheading:19709691-Humans, pubmed-meshheading:19709691-Hypothalamo-Hypophyseal System, pubmed-meshheading:19709691-Infusions, Intravenous, pubmed-meshheading:19709691-Insulin, pubmed-meshheading:19709691-Male, pubmed-meshheading:19709691-Memory, Short-Term, pubmed-meshheading:19709691-Middle Aged, pubmed-meshheading:19709691-Neuropsychological Tests, pubmed-meshheading:19709691-Neurosecretory Systems, pubmed-meshheading:19709691-Pituitary-Adrenal System
pubmed:year
2009
pubmed:articleTitle
Effects of glucose infusion on neuroendocrine and cognitive parameters in Addison disease.
pubmed:affiliation
Department of Internal Medicine I, University of Luebeck, 23538 Luebeck, Germany. Johanna.Klement@uk-sh.de
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't