Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-8-26
pubmed:abstractText
Alzheimer's disease (AD) is characterized by neuronal degeneration and cell loss. Abeta(42), in contrast to Abeta(40), is thought to be the pathogenic form triggering the pathological cascade in AD. In order to unravel overall gene regulation we monitored the transcriptomic responses to increased or decreased Abeta(40) and Abeta(42) levels, generated and derived from its precursor C99 (C-terminal fragment of APP comprising 99 amino acids) in human neuroblastoma cells. We identified fourteen differentially expressed transcripts by hierarchical clustering and discussed their involvement in AD. These fourteen transcripts were grouped into two main clusters each showing distinct differential expression patterns depending on Abeta(40) and Abeta(42) levels. Among these transcripts we discovered an unexpected inverse and strong differential expression of neurogenin 2 (NEUROG2) and KIAA0125 in all examined cell clones. C99-overexpression had a similar effect on NEUROG2 and KIAA0125 expression as a decreased Abeta(42)/Abeta(40) ratio. Importantly however, an increased Abeta(42)/Abeta(40) ratio, which is typical of AD, had an inverse expression pattern of NEUROG2 and KIAA0125: An increased Abeta(42)/Abeta(40) ratio up-regulated NEUROG2, but down-regulated KIAA0125, whereas the opposite regulation pattern was observed for a decreased Abeta(42)/Abeta(40) ratio. We discuss the possibilities that the so far uncharacterized KIAA0125 might be a counter player of NEUROG2 and that KIAA0125 could be involved in neurogenesis, due to the involvement of NEUROG2 in developmental neural processes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-10077635, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-10373225, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-10821917, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-11053242, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-11296300, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-11502253, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-11752450, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-11932745, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-12196135, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-12556458, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-12848929, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-14660786, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-15175243, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-15340159, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-15461798, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16227967, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16407118, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16410412, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16432899, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16537537, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-16646809, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-17070803, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-17403680, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-17581964, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-17994018, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-18253026, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-18448566, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-18591185, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-2687290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-29704, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-6137586, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-7573369, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-7695227, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-8350998, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-8590280, http://linkedlifedata.com/resource/pubmed/commentcorrection/19707560-9000438
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e6779
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering.
pubmed:affiliation
Center for Molecular Biology of the University of Heidelberg (ZMBH), Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't