Linked Life Data

19705375

Source:http://linkedlifedata.com/resource/pubmed/id/19705375

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-12-28
pubmed:abstractText
We evaluated the hemostatic efficacy of a biological self-assembling peptide RADA16-I in a rat kidney injury model. Adult male rats were randomized into five groups: sham operation (no renal excision), no hemostatic agent (control), commercially available gelatin sponge (Gelfoam), 1% RADA16-I, and 2% RADA16-I. After left partial nephrectomy, the anesthetized animal was anticoagulated using 300 IU x kg(-1) heparin, and the topical hemostatic agent was applied to the injury. Blood loss and mean arterial pressure (MAP) were recorded. As was the case for Gelfoam, 2% RADA16-I produced marked hemostasis versus controls (p < 0.01). Blood loss with 1% and 2% RADA16-I was significantly less than controls. The decline in MAP during surgery was less with 2% versus 1% RADA16-I. RADA16-I also resulted in less histological tissue responses than Gelfoam. These data suggest that RADA16-I can stop hemorrhage, with only minimal tissue responses, in experimental renal injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1616-5195
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Hemostatic efficacy of biological self-assembling peptide nanofibers in a rat kidney model.
pubmed:affiliation
Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Science Park No. 1, Ke Yuan 4th Street, Gao Peng Road, Hi-tech Industrial Development Zone, Chengdu, 610041, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't