Linked Life Data

19705362

Source:http://linkedlifedata.com/resource/pubmed/id/19705362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-8-31
pubmed:abstractText
Phenothiazine (PtzNH) and phenoxazine (PozNH) can protect human erythrocytes against hemolysis induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH), a peroxyl radical supplier. However, an antioxidant may be a pro-oxidant to accelerate the oxidation in the presence of radicals. The aim of this work is to assess whether PtzNH and PozNH have the potential to be pro-oxidants in AAPH-induced hemolysis of human erythrocytes. It has been found that high concentrations of PtzNH and PozNH employed were able to initiate hemolysis even in the absence of AAPH. In the presence of AAPH, the period of PtzNH and PozNH to lag hemolysis (t(lag)) decreased with the increase in the concentrations of PtzNH and PozNH, implicating that high concentration of PtzNH and PozNH accelerated hemolysis. So, PtzNH and PozNH played pro-oxidants' role in this case. Furthermore, high concentrations of AAPH employed made the pro-oxidant effect of PtzNH more remarkable. On the contrary, PozNH played a pro-oxidant role if only low concentration of AAPH was employed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1099-0461
pubmed:author
pubmed:copyrightInfo
2009 Wiley Periodicals, Inc.
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-6
pubmed:dateRevised
2011-3-18
pubmed:meshHeading
pubmed:articleTitle
Pro-oxidant effects of phenothiazine and phenoxazine on erythrocytes in the presence of peroxyl radical.
pubmed:affiliation
Department of Organic Chemistry, Jilin University, Changchun, People's Republic of China.
pubmed:publicationType
Journal Article