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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-8-25
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pubmed:abstractText |
The high degree of diversity of the hepatitis B virus (HBV) quasispecies in chronically infected individuals raises the possibility that HBV genetic variants favouring resistance to nucleoside/nucleotide analogues (NAs) might pre-exist to treatment. The aim of this study was to investigate the genetic variability of the entire HBV reverse transcriptase (RT) domain and of the overlapping S gene in a large series of untreated hepatitis B surface antigen carriers and in lamivudine (3TC)-resistant patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1359-6535
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-54
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pubmed:meshHeading |
pubmed-meshheading:19704167-Adult,
pubmed-meshheading:19704167-Aged,
pubmed-meshheading:19704167-Drug Resistance, Viral,
pubmed-meshheading:19704167-Female,
pubmed-meshheading:19704167-Genetic Variation,
pubmed-meshheading:19704167-Hepatitis B, Chronic,
pubmed-meshheading:19704167-Hepatitis B Surface Antigens,
pubmed-meshheading:19704167-Hepatitis B virus,
pubmed-meshheading:19704167-Humans,
pubmed-meshheading:19704167-Lamivudine,
pubmed-meshheading:19704167-Male,
pubmed-meshheading:19704167-Middle Aged,
pubmed-meshheading:19704167-Mutation,
pubmed-meshheading:19704167-RNA-Directed DNA Polymerase,
pubmed-meshheading:19704167-Reverse Transcriptase Inhibitors,
pubmed-meshheading:19704167-Sequence Analysis, DNA,
pubmed-meshheading:19704167-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Variability of reverse transcriptase and overlapping S gene in hepatitis B virus isolates from untreated and lamivudine-resistant chronic hepatitis B patients.
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pubmed:affiliation |
Unit of Clinical and Molecular Hepatology, Department of Internal Medicine, University of Messina, Messina, Italy. tpollicino@unime.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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