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rdf:type |
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lifeskim:mentions |
umls-concept:C0001407,
umls-concept:C0014898,
umls-concept:C0018893,
umls-concept:C0028621,
umls-concept:C0036315,
umls-concept:C0162388,
umls-concept:C0260127,
umls-concept:C0439596,
umls-concept:C0441655,
umls-concept:C1516048,
umls-concept:C1533691
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of (S)-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV and (S)-HPMPA enhance antischistosomal activity, we tested their alkoxyalkyl esters using Schistosoma mansoni worm killing in vitro. Hexadecyloxypropyl (HDP)-cyclic-(S)-HPMPA and HDP-cyclic-CDV exhibited significant in vitro antischistosomal activities and may offer promise alone or in combination with praziquantel.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-10389648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-11897580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-12121908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-12745133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-12927306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-14638494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-14742188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-14972516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-14996624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-15081944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-15105146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-15283988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-15633099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-15673748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-16153310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-16539388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-16790382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-16870786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-1699493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-17075334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-17846137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-18336926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-1857384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-1872902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-19289518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-19398648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-19425198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-410178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19704122-4952149
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1098-6596
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5284-7
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pubmed:dateRevised |
2011-2-16
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pubmed:meshHeading |
|
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pubmed:year |
2009
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pubmed:articleTitle |
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
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pubmed:affiliation |
Department of Pharmacology, Theodor Bilharz Research Institute, Warrak el-Hadar, Imbaba, Giza, Egypt.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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