| pubmed-article:19703901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19703901 | lifeskim:mentions | umls-concept:C1516988 | lld:lifeskim |
| pubmed-article:19703901 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:19703901 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:19703901 | pubmed:dateCreated | 2009-10-12 | lld:pubmed |
| pubmed-article:19703901 | pubmed:abstractText | Memory formation in the brain is thought to be depending upon long lasting plastic changes of synaptic contacts that require alterations on the transcriptional level. Here, we characterize LAPSER1, a putative cytokinetic tumor suppressor that binds directly to ProSAP2/Shank3 and the synaptic Rap-Gap protein SPAR1 as a novel postsynaptic density component. Postsynaptic LAPSER1 is in complex with all important members of the canonical Wnt pathway including beta-catenin. Upon N-methyl-D-aspartate receptor-dependent activation, LAPSER1 and beta-catenin comigrate from the postsynaptic density to the nucleus and induce the transcription and translation of known beta-catenin target genes, including Tcfe2a and c-Myc. The nuclear export and cytoplasmic redistribution of beta-catenin is tightly regulated by LAPSER1. We postulate a postsynaptic cross-talk between N-methyl-D-aspartate receptors and a LAPSER1-beta-catenin complex that results in a self-regulated, synaptic activity-dependent expression of beta-catenin target genes. This calls for a novel role of Tcfe2a and c-Myc in plastic changes of neural tissue. | lld:pubmed |
| pubmed-article:19703901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19703901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19703901 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19703901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19703901 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19703901 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19703901 | pubmed:author | pubmed-author:BoeckersTobia... | lld:pubmed |
| pubmed-article:19703901 | pubmed:author | pubmed-author:BockmannJuerg... | lld:pubmed |
| pubmed-article:19703901 | pubmed:author | pubmed-author:SchmeisserMic... | lld:pubmed |
| pubmed-article:19703901 | pubmed:author | pubmed-author:GrabruckerAnd... | lld:pubmed |
| pubmed-article:19703901 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19703901 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:19703901 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:19703901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19703901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19703901 | pubmed:pagination | 29146-57 | lld:pubmed |
| pubmed-article:19703901 | pubmed:dateRevised | 2010-10-19 | lld:pubmed |
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| pubmed-article:19703901 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19703901 | pubmed:articleTitle | Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. | lld:pubmed |
| pubmed-article:19703901 | pubmed:affiliation | Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany. | lld:pubmed |
| pubmed-article:19703901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19703901 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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