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rdf:type |
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lifeskim:mentions |
umls-concept:C0001511,
umls-concept:C0018957,
umls-concept:C0021701,
umls-concept:C0023884,
umls-concept:C0038250,
umls-concept:C0086418,
umls-concept:C0443264,
umls-concept:C0851827,
umls-concept:C1185625,
umls-concept:C1332710,
umls-concept:C1332712,
umls-concept:C1332822,
umls-concept:C1332823,
umls-concept:C1701901
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pubmed:issue |
4
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pubmed:dateCreated |
2009-9-15
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pubmed:abstractText |
Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order to maximize the engraftment of cells for clinical applications it is necessary to understand the molecular mechanisms that regulate stem cell recruitment and retention. Our aim therefore was to determine which factors where involved in adhesion of circulating HSC to liver endothelium and sequestration around epithelial cells within the liver.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/CD44 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
734-49
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pubmed:meshHeading |
pubmed-meshheading:19703720-Antigens, CD18,
pubmed-meshheading:19703720-Antigens, CD34,
pubmed-meshheading:19703720-Antigens, CD44,
pubmed-meshheading:19703720-Biliary Tract,
pubmed-meshheading:19703720-Cell Adhesion,
pubmed-meshheading:19703720-Cell Line,
pubmed-meshheading:19703720-Endothelial Cells,
pubmed-meshheading:19703720-Hematopoietic Stem Cells,
pubmed-meshheading:19703720-Humans,
pubmed-meshheading:19703720-Integrin alpha4beta1,
pubmed-meshheading:19703720-Integrins,
pubmed-meshheading:19703720-Intercellular Adhesion Molecule-1,
pubmed-meshheading:19703720-Ligands,
pubmed-meshheading:19703720-Liver,
pubmed-meshheading:19703720-Receptors, CXCR3,
pubmed-meshheading:19703720-Receptors, CXCR4,
pubmed-meshheading:19703720-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2009
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pubmed:articleTitle |
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
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pubmed:affiliation |
Centre for Liver Research and NIHR Biomedical Research Unit for Liver Disease, University of Birmingham and Queen Elizabeth Hospital Birmingham, Birmingham B15 2TT, UK. h.a.crosby@bham.ac.uk
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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