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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8697
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pubmed:dateCreated |
1990-5-31
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pubmed:abstractText |
Human herpesvirus-6 (HHV-6) was recovered at high frequency (greater than 85%) from the saliva of both healthy individuals and those infected with the human immunodeficiency virus (HIV). The level of isolation mirrored the high prevalence of antibodies to HHV-6 found in sera obtained from residents of diverse areas of the world. Seroconversion occurred between 1 and 3 years of age; seroprevalence ranged between 80% and 100% among adults under 40 and decreased to 35% between ages 62 and 88. Serum titres in healthy individuals remained stable during periods of virus shedding. Immune cellular dysfunction in patients was associated with high geometric mean HHV-6 antibody titres. These observations suggest that HHV-6 infection takes place within the first 3 years of life, and strongly implicate oral shedding as a common means of transmission of this newly described herpesvirus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
335
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1047-50
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1970369-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1970369-Adolescent,
pubmed-meshheading:1970369-Adult,
pubmed-meshheading:1970369-Age Factors,
pubmed-meshheading:1970369-Aged,
pubmed-meshheading:1970369-Aged, 80 and over,
pubmed-meshheading:1970369-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1970369-Antibodies, Viral,
pubmed-meshheading:1970369-Antigens, Viral,
pubmed-meshheading:1970369-Child,
pubmed-meshheading:1970369-Child, Preschool,
pubmed-meshheading:1970369-Cross-Sectional Studies,
pubmed-meshheading:1970369-Evaluation Studies as Topic,
pubmed-meshheading:1970369-Herpesviridae Infections,
pubmed-meshheading:1970369-Herpesvirus 6, Human,
pubmed-meshheading:1970369-Homosexuality,
pubmed-meshheading:1970369-Humans,
pubmed-meshheading:1970369-Infant,
pubmed-meshheading:1970369-Leukocytes, Mononuclear,
pubmed-meshheading:1970369-Male,
pubmed-meshheading:1970369-Middle Aged,
pubmed-meshheading:1970369-Saliva,
pubmed-meshheading:1970369-San Francisco,
pubmed-meshheading:1970369-Virus Replication
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pubmed:year |
1990
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pubmed:articleTitle |
Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population.
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pubmed:affiliation |
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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