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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-19
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pubmed:abstractText |
Multiple myeloma (MM) is a B-lymphocyte neoplasia that is presently incurable because the tumor cells become resistant to currently available drugs. The growth and survival signals resulting from interactions between the malignant clones and the bone marrow microenvironment are mediated chiefly through the phosphoinositide 3'-kinase/Akt kinase signaling pathway. Thus agents that can abrogate this pathway have great potential as targeted therapies. A novel approach in this regard is through activation of the Src homology 2-containing inositol 5'-phosphatase (SHIP), using the small molecule agonist, AQX-MN100.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/AQX MN100,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Boronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/bortezomib,
http://linkedlifedata.com/resource/pubmed/chemical/inositol 3,4,5-trisphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/inositol-1,4,5-trisphosphate...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-2399
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1274-83
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19703514-Animals,
pubmed-meshheading:19703514-Antineoplastic Agents,
pubmed-meshheading:19703514-Apoptosis,
pubmed-meshheading:19703514-B-Lymphocytes,
pubmed-meshheading:19703514-Boronic Acids,
pubmed-meshheading:19703514-Cell Line, Tumor,
pubmed-meshheading:19703514-DNA Replication,
pubmed-meshheading:19703514-Dexamethasone,
pubmed-meshheading:19703514-Drug Screening Assays, Antitumor,
pubmed-meshheading:19703514-Drug Synergism,
pubmed-meshheading:19703514-Enzyme Activation,
pubmed-meshheading:19703514-Humans,
pubmed-meshheading:19703514-Inositol Phosphates,
pubmed-meshheading:19703514-Mice,
pubmed-meshheading:19703514-Multiple Myeloma,
pubmed-meshheading:19703514-Neoplasm Proteins,
pubmed-meshheading:19703514-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19703514-Phosphoric Monoester Hydrolases,
pubmed-meshheading:19703514-Phosphorylation,
pubmed-meshheading:19703514-Polycyclic Compounds,
pubmed-meshheading:19703514-Protein Processing, Post-Translational,
pubmed-meshheading:19703514-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19703514-Pyrazines,
pubmed-meshheading:19703514-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Activation of SHIP via a small molecule agonist kills multiple myeloma cells.
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pubmed:affiliation |
Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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