Linked Life Data

19703301

Source:http://linkedlifedata.com/resource/pubmed/id/19703301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-9-25
pubmed:abstractText
Rho signaling regulates key cellular processes including proliferation, survival, and migration, and it has been implicated in the development of many types of cancer including breast cancer. P190B Rho GTPase activating protein (RhoGAP) functions as a major inhibitor of the Rho GTPases. P190B is required for mammary gland morphogenesis, and overexpression of p190B in the mammary gland induces hyperplastic lesions. Hence, we hypothesized that p190B may play a pivotal role in mammary tumorigenesis.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1465-542X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R61
pubmed:dateRevised
2011-2-11
pubmed:meshHeading
pubmed-meshheading:19703301-Adenocarcinoma, pubmed-meshheading:19703301-Animals, pubmed-meshheading:19703301-Crosses, Genetic, pubmed-meshheading:19703301-Disease Progression, pubmed-meshheading:19703301-Epithelial Cells, pubmed-meshheading:19703301-Female, pubmed-meshheading:19703301-GTPase-Activating Proteins, pubmed-meshheading:19703301-Heterozygote, pubmed-meshheading:19703301-Mammary Neoplasms, Experimental, pubmed-meshheading:19703301-Mammary Tumor Virus, Mouse, pubmed-meshheading:19703301-Mice, pubmed-meshheading:19703301-Mice, Mutant Strains, pubmed-meshheading:19703301-Mice, SCID, pubmed-meshheading:19703301-Neoplasm Proteins, pubmed-meshheading:19703301-Neoplasm Transplantation, pubmed-meshheading:19703301-Neovascularization, Pathologic, pubmed-meshheading:19703301-Receptor, erbB-2, pubmed-meshheading:19703301-Signal Transduction, pubmed-meshheading:19703301-Stromal Cells, pubmed-meshheading:19703301-Thrombospondin 1
pubmed:year
2009
pubmed:articleTitle
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
pubmed:affiliation
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. bheckmanstoddard@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural