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pubmed-article:1970307pubmed:abstractTextPrimary allo-stimulation induces substantial and differentiated modifications in the development of cytoplasmic organelles of peripheral T-lymphocyte subsets. The present computer-assisted image analysis provides evidence that the CD4+ subset undergoes significant increase in organelle density after stimulation, while the CD8+ subset exhibits a post-stimulation organelle development proportional to the cell size. Each immunological subset contains two distinct patterns of cytoplasmic organization, here defined as type I (containing a few cytoplasmic organelles) and type II (with well-developed synthesis and storage organelles). On the basis of these findings cytologic parameters could be ascribed to a heterogeneous proliferation of functionally distinct T-cell clones in CD4+ and CD8+ subsets.lld:pubmed
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pubmed-article:1970307pubmed:pagination179-85lld:pubmed
pubmed-article:1970307pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1970307pubmed:year1990lld:pubmed
pubmed-article:1970307pubmed:articleTitleAllo-activated CD4+ and CD8+ lymphocyte subsets: new ultrastructural findings based on computer-assisted image analysis.lld:pubmed
pubmed-article:1970307pubmed:affiliationInstitute of Human Anatomy and Histology, University of Verona, Italy.lld:pubmed
pubmed-article:1970307pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1970307pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed