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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024305,
umls-concept:C0040287,
umls-concept:C0078058,
umls-concept:C0169539,
umls-concept:C0185117,
umls-concept:C0220901,
umls-concept:C0220927,
umls-concept:C0378516,
umls-concept:C0388911,
umls-concept:C0441889,
umls-concept:C0449560,
umls-concept:C0449774,
umls-concept:C0597357,
umls-concept:C1256770,
umls-concept:C1334306,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor C,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1029-2403
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1647-60
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pubmed:meshHeading |
pubmed-meshheading:19701853-Aged,
pubmed-meshheading:19701853-Cell Nucleus,
pubmed-meshheading:19701853-Cytoplasm,
pubmed-meshheading:19701853-Female,
pubmed-meshheading:19701853-Gene Expression Profiling,
pubmed-meshheading:19701853-Humans,
pubmed-meshheading:19701853-Lymph Nodes,
pubmed-meshheading:19701853-Lymphoma, Follicular,
pubmed-meshheading:19701853-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:19701853-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:19701853-Male,
pubmed-meshheading:19701853-Middle Aged,
pubmed-meshheading:19701853-Neoplasm Proteins,
pubmed-meshheading:19701853-Neovascularization, Pathologic,
pubmed-meshheading:19701853-Prognosis,
pubmed-meshheading:19701853-RNA, Messenger,
pubmed-meshheading:19701853-RNA, Neoplasm,
pubmed-meshheading:19701853-Retrospective Studies,
pubmed-meshheading:19701853-Vascular Endothelial Growth Factor A,
pubmed-meshheading:19701853-Vascular Endothelial Growth Factor C,
pubmed-meshheading:19701853-Vascular Endothelial Growth Factor Receptor-1,
pubmed-meshheading:19701853-Vascular Endothelial Growth Factor Receptor-2
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pubmed:year |
2009
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pubmed:articleTitle |
Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas.
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pubmed:affiliation |
Department of Hematology, Aarhus University Hospital, Aarhus DK-8000, Denmark.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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