Source:http://linkedlifedata.com/resource/pubmed/id/19701677
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-11-12
|
| pubmed:abstractText |
We prospectively tested, at diagnosis in essential thrombocythemia (ET) patients with no clear indication to platelet (PLT)-lowering treatment, a scoring system based on age, PLT level, cardiovascular diseases, previous thrombotic events, smoking and dysmetabolic diseases. From 04/92 to 03/98, 168 consecutive patients were enrolled. Hydroxyurea (HU) was started at diagnosis in 32 "symptomatic" patients and in 33 patients aged >70 years. The remaining 103 patients ("asymptomatic" and aged <70 years) were classified according to our scoring system. Thirty-two patients with score > or = 4 started HU early after diagnosis. The remaining 71 patients with score <4 at diagnosis received anti-aggregating agents only; of them, 24 (33.8%) started HU during follow-up after a median time from diagnosis of 28 months, while 47 (66.2%) did not start any PLT-lowering treatment. Thrombotic complications occurred in 9/103 patients (8.7%); in particular, they occurred in 4/32 patients (12.5%) with score > or = 4 receiving HU since diagnosis and in 5/71 (7%) with score <4 under anti-aggregating agents only. This scoring system appears effective to discriminate a different risk of thrombotic events, and could be useful to decide when a PLT-lowering therapy needs to be started.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1865-3774
|
| pubmed:author |
pubmed-author:AlimenaGiulianaG,
pubmed-author:BiondoFrancescaF,
pubmed-author:BrecciaMassimoM,
pubmed-author:CarmosinoIdaI,
pubmed-author:FamaAngeloA,
pubmed-author:LatagliataRobertoR,
pubmed-author:MazzucconiMaria GabriellaMG,
pubmed-author:NapoleoneLauraL,
pubmed-author:PettiMaria ConcettaMC,
pubmed-author:RagoAngelaA,
pubmed-author:SantoroCristinaC,
pubmed-author:SpadeaAntonioA,
pubmed-author:StefanizziCaterinaC,
pubmed-author:VolpicelliPaolaP,
pubmed-author:VozellaFedericoF
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
486-91
|
| pubmed:meshHeading |
pubmed-meshheading:19701677-Adult,
pubmed-meshheading:19701677-Aged,
pubmed-meshheading:19701677-Aged, 80 and over,
pubmed-meshheading:19701677-Aging,
pubmed-meshheading:19701677-Blood Platelets,
pubmed-meshheading:19701677-Cardiovascular Diseases,
pubmed-meshheading:19701677-Clinical Protocols,
pubmed-meshheading:19701677-Female,
pubmed-meshheading:19701677-Follow-Up Studies,
pubmed-meshheading:19701677-Humans,
pubmed-meshheading:19701677-Hydroxyurea,
pubmed-meshheading:19701677-Male,
pubmed-meshheading:19701677-Metabolic Diseases,
pubmed-meshheading:19701677-Middle Aged,
pubmed-meshheading:19701677-Platelet Aggregation Inhibitors,
pubmed-meshheading:19701677-Platelet Count,
pubmed-meshheading:19701677-Risk Factors,
pubmed-meshheading:19701677-Smoking,
pubmed-meshheading:19701677-Survival Analysis,
pubmed-meshheading:19701677-Thrombocythemia, Essential,
pubmed-meshheading:19701677-Thrombosis,
pubmed-meshheading:19701677-Treatment Outcome
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Decisional flow with a scoring system to start platelet-lowering treatment in patients with essential thrombocythemia: long-term results.
|
| pubmed:affiliation |
Department of Cellular Biotechnology and Hematology, University La Sapienza, Via Benevento 6, 00161 Rome, Italy. rob.lati@libero.it
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|