|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0028040,
umls-concept:C0039859,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0243072,
umls-concept:C0243077,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C0909868,
umls-concept:C1533691,
umls-concept:C1883254
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|
pubmed:issue |
9
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pubmed:dateCreated |
2009-9-4
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|
pubmed:abstractText |
To design and synthese a novel class of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors, featuring the (phenylsulfonamido-methyl)pyridine and (phenylsulfonamido-methyl)thiazole framework.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1745-7254
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1344-50
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pubmed:meshHeading |
pubmed-meshheading:19701236-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:19701236-Animals,
pubmed-meshheading:19701236-Binding Sites,
pubmed-meshheading:19701236-Biological Assay,
pubmed-meshheading:19701236-Humans,
pubmed-meshheading:19701236-Mice,
pubmed-meshheading:19701236-Microsomes,
pubmed-meshheading:19701236-Nicotine,
pubmed-meshheading:19701236-Scintillation Counting,
pubmed-meshheading:19701236-Structure-Activity Relationship,
pubmed-meshheading:19701236-Thiazoles
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pubmed:year |
2009
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|
pubmed:articleTitle |
Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro.
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|
pubmed:affiliation |
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
